Research Library

Research in COVID-19 has answered many of the questions that kept popping up in POTS, Fibromyalgia and similar conditions- how a virus (or trauma, mould, parasites, sustained stress) can activate threat receptors (Toll-like receptors, or TLRs) which then activate Mast Cells that are responsible for the cytokine storm that is what happens in COVID.

Presented below are our latest research articles:

Graham Exelby

POTS Part 5 Comorbidities

Dr Graham Exelby March 2025 Introduction to POTS Comorbidities Postural Orthostatic Tachycardia Syndrome (POTS) exists not as an isolated...

Graham Exelby

POTS Part 4 Symptoms

Dr Graham Exelby March 2025 Introduction Postural Orthostatic Tachycardia Syndrome (POTS) can be conceptualized as a disorder of...

Graham Exelby

POTS Part 3 Activators

Dr Graham Exelby March 2025 Abstract Background: Postural Orthostatic Tachycardia Syndrome (POTS) is a heterogenous dysautonomic...

Graham Exelby

POTS Part 2 Unifying Hypotheses

A Unified Model of Hypoxia, Neuroimmune Dysregulation and Autonomic Dysfunction in POTS, Long COVID, and Fibromyalgia Abstract : This...

Graham Exelby

POTS Part 1: Epidemiology and Overview

Dr Graham Exelby March 2025 Part of major review of POTS based on causes, drivers demonstrating the linking between inflammation, immune...

GABA dysfunction in POTS, Long COVID, Fibromyalgia and Long COVID

Graham Exelby

GABA dysfunction in POTS, Long COVID, Fibromyalgia and Long COVID

Dr Graham Exelby December 2024 Abstract GABA (γ-aminobutyric acid), the primary inhibitory neurotransmitter in the central nervous...

Sensitization in POTS, Long COVID and Fibromyalgia

Graham Exelby

Sensitization in POTS, Long COVID and Fibromyalgia

Dr Graham Exelby December 2024 Abstract Central sensitization, characterized by increased responsiveness of the central nervous system...

Graham Exelby

Lymphatic and CSF Canalicular Systems

due for release January 1 2025

Graham Exelby

Assembling the Pieces of POTS

Dr Graham Exelby December 2024 Due for release in 2025. The paper has been expanded to incorporate all major aspects of POTS including...

Graham Exelby

Heat and Cold Intolerance

Dr Graham Exelby December 2024 Temperature intolerance is a common symptom in Postural Orthostatic Tachycardia Syndrome (POTS) and often...

Targeting the Perfect Storm- Amino Acid Dysfunction in Post Exertional Malaise-

Graham Exelby

Targeting the Perfect Storm- Amino Acid Dysfunction in Post Exertional Malaise-

Dr Graham Exelby. December 2024, revised February 2025 Introduction Post-exertional malaise (PEM) represents a multifactorial challenge...

Graham Exelby

References for Brainstem Hypoperfusion, Coat Hanger Pain and PEM.

Graham Exelby September 2024 References: 1. Hira, R et al. Objective Hemodynamic Cardiovascular Autonomic Abnormalities in...

Brainstem Hypoperfusion, Coat hanger pain and Post-Exertional Malaise in POTS and Long COVID

Graham Exelby

Brainstem Hypoperfusion, Coat hanger pain and Post-Exertional Malaise in POTS and Long COVID

Dr Graham Exelby September 2024 Brainstem hypoperfusion, coat hanger pain and PEM have similar pathogenesis, and are found in that same...

Mould, Sustained Stress and PTSD in Immune Dysregulation

Graham Exelby

Mould, Sustained Stress and PTSD in Immune Dysregulation

Dr Graham Exelby September 2024 In the complex pathophysiology that lies beneath POTS, Fibromyalgia and their comorbidities, persistent...

Graham Exelby

Intracranial Hypertension- the Link betweenVascular and CSF Dysfunction

currently in pre-release form being peer-reviewed, this discusses the link between the pressure experienced in POTS, FMS and ME/CFS and...

Amino Acid, Essential Vitamin and Mineral Burn off in Post Exertional Malaise

Graham Exelby

Amino Acid, Essential Vitamin and Mineral Burn off in Post Exertional Malaise

A Preliminary Study -September 2024, currently being peer-reviewed Dr Graham Exelby Brainstem hypoperfusion, coat hanger pain and PEM...

Graham Exelby

The Genetic Basis to Improving Toxin Detoxification

Your genetics determine if the body can clear toxins efficiently. Dr Valerio Vittone (PH.D) January 2023 Clearance of toxic compounds...

Graham Exelby

Long COVID Immune Dysfunction

This is the first part of a series of articles dealing with Long COVID and its management Dr Graham Exelby and Dr Valerio Vittone May...

Graham Exelby

Management of Long COVID Cognitive Impairment

Dr Graham Exelby May 2024 This paper is part 3 of a series looking at the immune dysfunction, causes of cognitive impairment and other...

Causes of Long COVID Cognitive Impairment

Graham Exelby

Causes of Long COVID Cognitive Impairment

Dr Graham Exelby May 2024 This paper is part 2 of a series looking at the immune dysfunction, causes of cognitive impairment and other...

Articles

POTS Part 5 Comorbidities

POTS MAIN FOLIO

POTS Part 4 Symptoms

POTS MAIN FOLIO

POTS Part 3 Activators

POTS MAIN FOLIO

POTS Part 2 Unifying Hypotheses

Research Library

POTS Part 5 Comorbidities

POTS Part 4 Symptoms

POTS Part 3 Activators

POTS Part 2 Unifying Hypotheses

POTS Part 1: Epidemiology and Overview

GABA dysfunction in POTS, Long COVID, Fibromyalgia and Long COVID

Sensitization in POTS, Long COVID and Fibromyalgia

Lymphatic and CSF Canalicular Systems

Assembling the Pieces of POTS

Heat and Cold Intolerance

Targeting the Perfect Storm- Amino Acid Dysfunction in Post Exertional Malaise-

References for Brainstem Hypoperfusion, Coat Hanger Pain and PEM.

Brainstem Hypoperfusion, Coat hanger pain and Post-Exertional Malaise in POTS and Long COVID

Mould, Sustained Stress and PTSD in Immune Dysregulation

Intracranial Hypertension- the Link betweenVascular and CSF Dysfunction

Amino Acid, Essential Vitamin and Mineral Burn off in Post Exertional Malaise

The Genetic Basis to Improving Toxin Detoxification

Long COVID Immune Dysfunction

Management of Long COVID Cognitive Impairment

Causes of Long COVID Cognitive Impairment

Categories

Articles

POTS Part 5 Comorbidities

POTS Part 4 Symptoms

POTS Part 3 Activators

POTS Part 2 Unifying Hypotheses

POTS Part 1: Epidemiology and Overview

GABA dysfunction in POTS, Long COVID, Fibromyalgia and Long COVID

Sensitization in POTS, Long COVID and Fibromyalgia

Lymphatic and CSF Canalicular Systems

Assembling the Pieces of POTS

Heat and Cold Intolerance

Targeting the Perfect Storm- Amino Acid Dysfunction in Post Exertional Malaise-

References for Brainstem Hypoperfusion, Coat Hanger Pain and PEM.

Brainstem Hypoperfusion, Coat hanger pain and Post-Exertional Malaise in POTS and Long COVID

Mould, Sustained Stress and PTSD in Immune Dysregulation

Intracranial Hypertension- the Link betweenVascular and CSF Dysfunction

Amino Acid, Essential Vitamin and Mineral Burn off in Post Exertional Malaise

The Genetic Basis to Improving Toxin Detoxification

Long COVID Immune Dysfunction

Management of Long COVID Cognitive Impairment

Causes of Long COVID Cognitive Impairment

Breaking Through in POTS and Long Covid

Management of Fibromyalgia and Co-Morbidities

Fibromyalgia Syndrome and the Linking with POTS and Chronic Fatigue Syndrome-References

Fibromyalgia Syndrome and the Linking with POTS and Chronic Fatigue Syndrome- Part 1

Fibromyalgia Syndrome and the Linking with POTS and Chronic Fatigue Syndrome-Part 2

Fibromyalgia Syndrome and the Linking with POTS and Chronic Fatigue Syndrome-Part 3

Fibromyalgia Syndrome and the Linking with POTS and Chronic Fatigue Syndrome-Part 4

Intra-Abdominal Vascular Compression Syndromes

Internal Jugular Vein Dysfunction- Jugular Outlet Syndrome, Internal Jugular Vein Stenosis and Obstruction

Intracranial Hypertension, Intracranial Hypotension and Craniovascular Pressure Change

The Glymphatic System

Cervical Spine Abnormality, Ehlers-Danlos Syndrome and Vertebral Vascular and Lymphatic Dysfunction

Low Glutamate Diet

Managing POTS

DNA Mutations that Underpin POTS and Long Covid

QT Prolongation

Heart Rate Variability

DNA Mutations in POTS and Long Covid-Practitioner version MCAS Conference- April 2 2023-

DNA Mutations in POTS and Long Covid- Patient version-MCAS Conference- April 2 2023

Nigella Sativa in COVID

Nicotinamide Mononucleotide (NMN)

Low Dose Naltrexone, Ketotifen and other Mast Cell Treatments

Thoracic Outlet Syndrome (incorporating Costoclavicular Syndrome)

Migraine

A 50 Year Journey in Medicine